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P140
Cat. No. PP-480
Structure:
H-Arg-Ile-His-Met-Val-Tyr-Ser-Lys-Arg-Ser-(PO3)-Gly-Lys-Pro-Arg-Gly-Tyr-Ala-Phe-Ile-Glu-Tyr-OH
Other Names:
Phosphopeptide P140, CEP 33457, Forigerimod, IPP 201101
Activity:
HSPA8/HSC70 chaperone binder
P140 is a peptide from the small nuclear ribonucleoprotein U1-70K, phosphorylated at the Ser140 position. P140 binds to the HSPA8/HSC70 chaperone protein, a constitutively expressed, cognate protein of the HSP70 family, which is involved in many cellular processes and has a key regulatory role in autophagy. Both in vitro and in vivo, P140 interferes with hyperactivated chaperone-mediated autophagy, modifying overexpression of major histocompatibility complex class II molecules and antigen presentation to autoreactive T cells. In a lupus prone murine model, P140 displays tolerogenic and immunomodulatory effects, depleting hyperactivated autoreactive T and B cells and restoring normal immune homeostasis. P140 decreases proteinuria and anti-DNA antibody production, and significantly prolongs survival.
Monneaux et al (2003) T cell recognition and therapeutic effect of a phosphorylated synthetic peptide of the 70K snRNP protein administered in MR/lpr mice. Eur J Immunol. 33(2) 287 PMID: 12548559
Zimmer et al (2013) Lupuzor/P140 peptide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled phase IIb clinical trial. Ann Rheum Dis. 72(11) 1830 PMID: 23172751
Schall et al (2022) P140 Peptide Leads to Clearance of Autoreactive Lymphocytes and Normalizes Immune Response in Lupus-Prone Mice. Front Immunol. 13 904669 PMID: 35720371
Related areas
All peptides >
All protein-protein interaction modulators >
All regulated cell death categories >
All immunology research categories >
Licencing Information
We are not able to supply this product to individuals or residential addresses. Please refer to our terms of product use.
Technical Data
| Structure | H-Arg-Ile-His-Met-Val-Tyr-Ser-Lys-Arg-Ser-(PO3)-Gly-Lys-Pro-Arg-Gly-Tyr-Ala-Phe-Ile-Glu-Tyr-OH |
| CAS Number | 497156-60-2 |
| Molecular Weight | 2638.94 |
| Formula | C117H181N32O32PS |
| Sequence | RIHMVYSKRS(PO3)GKPRGYAFIEY |
| Modifications | Phosphono group at serine 10 |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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