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Products
Pharmacology
Type
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- Technical support
- Resources
FNIII14
Cat. No. IG-080
Structure:
H-Thr-Glu-Ala-Thr-Ile-Thr-Gly-Leu-Glu-Pro-Gly-Thr-Glu-Tyr-Thr-Ile-Tyr-Val-Ile-Ala-Leu-OH
Other Names:
Peptide III14-2
Activity:
Inactivates β1 integrins
FNIII14 is a peptide derived from the 14th fibronectin type III-like (FN-III) repeat of fibronectin, a functional site usually hidden but exposed by conformational changes and proteolytic cleavage. FNIII14 can switch β1- integrin from the active to the inactive form, resulting in functional inactivation of integrin signalling by a mechanism distinct from that of conventional antagonists. Inactivation of β1-integrins by peptide FNIII14 exerts potent anti-cancer effects in various solid tumours and hematologic malignancies both in vitro and in vivo, including suppression of survival, proliferation, migration, invasion and myc expression, potentiation of other anti cancer activity, inhibition of metastasis, disuption of cell adhesion mediated drug resistance to cytosine arabinoside and suppression of tumour onset.
Fukai et al (1997) Identification of the anti-adhesive site buried within the heparin-binding domain of fibronectin. J Biochem. 121(2) 189 PMID: 9089388
Fujita (2020) Involvement of Integrin-Activating Peptides Derived from Tenascin-C in Cancer Aggression and New Anticancer Strategy Using the Fibronectin-Derived Integrin-Inactivating Peptide. Molecules 25(14) 3239 PMID: 32708610
Fujita et al (2021) Biofunctional Peptide FNIII14: Therapeutic Potential. Encyclopedia 1(2) 350 https://doi.org/10.3390/encyclopedia1020029
Related areas
All peptides >
All integrin receptor modulators >
All cancer research areas >
Technical Data
| Structure | H-Thr-Glu-Ala-Thr-Ile-Thr-Gly-Leu-Glu-Pro-Gly-Thr-Glu-Tyr-Thr-Ile-Tyr-Val-Ile-Ala-Leu-OH |
| CAS Number | 206536-96-1 |
| Molecular Weight | 2254.16 |
| Formula | C103H163N21O35 |
| Sequence | TEATITGLEPGTEYTIYVIAL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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