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Products
Pharmacology
Type
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- Technical support
- Resources
NAF-1 44-67
Cat. No. CP-050
Structure:
H-Phe-Leu-Gly-Val-Leu-Ala-Leu-Leu-Gly-(D)Tyr-Leu-Ala-Val-Arg-Pro-(D)Phe-Leu-Pro-Lys-(D)Lys-Lys-Gln-Gln-Lys-OH
Other Names:
3D-NAF-1 44-67
Activity:
Targets cancer cell mitochondria and ER
NAF-1 44-67 is derived from the transmembrane and flexible loop regions of the human mitochondrial/ER membrane-anchored NEET protein, Nutrient Autophagy Factor 1 (NAF-1), with d amino acid residues incorporated into its sequence to improve stability in biological systems. NAF-1 44-67 selectively permeates through the plasma membranes of human epithelial breast cancer cells and targets their mitochondria and ER, triggering cell death with characteristics of apoptosis, ferroptosis and necroptosis. The specificity of NAF-1 44-67 towards cancer cells is due to it being derived from the NAF-1 sequence that resides in the mitochondrial and ER membranes. In vivo NAF-1 44-67 significantly decreases tumour growth in xenograft mice carrying human triple-negative breast cancer MDA-MB-231 tumours.
Sohn et al (2022) A peptide-derived strategy for specifically targeting the mitochondria and ER of cancer cells: a new approach in fighting cancer. Chem Sci. 13(23) 6929 PMID: 35774163
Rowland et al (2023) A combination of a cell penetrating peptide and a protein translation inhibitor kills metastatic breast cancer cells. Cell Death Discov. 9(1) 325 PMID: 37652915
Related areas
All cell penetrating peptides >
All protein-protein interaction modulators >
All cancer research categories >
All regulated cell death categories >
Technical Data
| Structure | H-Phe-Leu-Gly-Val-Leu-Ala-Leu-Leu-Gly-(D)Tyr-Leu-Ala-Val-Arg-Pro-(D)Phe-Leu-Pro-Lys-(D)Lys-Lys-Gln-Gln-Lys-OH |
| Molecular Weight | 2726.67 |
| Formula | C133H219N33O28 |
| Sequence | FLGVLALLGyLAVRPfLPKkKQQK |
| Modifications | Tyrosine 10, phenylalaine 16 and lysine 20 are D amino acids |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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