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TNIIIA2
Cat. No. IG-070
Structure:
H-Arg-Ser-Thr-Asp-Leu-Pro-Gly-Leu-Lys-Ala-Ala-Thr-His-Tyr-Thr-Ile-Thr-Ile-Arg-Gly-Val-Cys-OH
Activity:
β1 integrin activator
TNIIIA2 is a peptide derived from the matricellular protein tenascin-C, a protein which is highly expressed in inflammatory bowel diseases including colorectal cancer, where tenascin-C expression level is correlated with poor prognosis. TNIIIA2 induces potent and sustained activation of β1 integrin and promotes invasion and metastasis in colon cancer cells, and causes acquisition of aggressive behaviour, dysregulated proliferation, and migration in glioblastoma cells. In an osteoarthritis mouse model, TNIIIA2 upregulates the expression of tumour necrosis factor-α, matrix metalloproteinase 3, and basic fibroblast growth factor and prevents articular cartilage degeneration without inducing synovitis.
Saito (2007) A peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4. J Biol Chem. 282(48) 34929 PMID: 17901052
Fujita et al (2019) Aggressive Progression in Glioblastoma Cells through Potentiated Activation of Integrin α5β1 by the Tenascin-C-Derived Peptide TNIIIA2. Mol Cancer Ther. 18(9) 1649 PMID: 31189613
Hattori et al (2021) The Peptide of Tenascin-C, as a Candidate for Preventing Articular Cartilage Degeneration. Cartilage 13(2_suppl) 1367S PMID: 32204600
Related areas
All peptides >
All integrin receptor modulators >
All cancer research categories >
All immunology research categories >
Technical Data
| Structure | H-Arg-Ser-Thr-Asp-Leu-Pro-Gly-Leu-Lys-Ala-Ala-Thr-His-Tyr-Thr-Ile-Thr-Ile-Arg-Gly-Val-Cys-OH |
| CAS Number | 876594-05-7 |
| Molecular Weight | 2373.73 |
| Formula | C103H173N31O31 S |
| Sequence | RSTDLPGLKAATHYTITIRGVC |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in saline |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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