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Products
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- Technical support
- Resources
iSP2
Cat. No. PP-470
Structure:
H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Trp-Pro-Val-Ile-Leu-OH
Other Names:
STAP-2-derived synthetic peptide, R8-SP2-332/336, R8 STAP-2 C332/336
Activity:
STAP-2 - CD3zeta ITAM interaction blocker
iSP2 is a peptide derived from residues of signal-transducing adaptor protein-2 (STAP-2) identified as interacting with cluster of differentiation 3 zeta (CD3zeta) immunoreceptor tyrosine based activation motifs (ITAMs) conjugated to octa-arginine to enhance cell penetrating ability. STAP-2 is an adaptor protein that positively regulates T-cell receptor (TCR) signaling by associating with TCR proximal CD3zeta ITAMs and lymphocyte-specific protein tyrosine kinase. iSP2 directly interacts with the ITAM sequence and competitively inhibits STAP-2 - CD3zeta ITAMs interaction and decreases TCR activation in human and murine T cells. In murine models of experimental autoimmune encephalomyelitis, iSP2 significantly suppresses disease development, to a similar extent to that seen in STAP-2 knockout mice.
Sasaki et al (2023) STAP-2-Derived Peptide Suppresses TCR-Mediated Signals to Initiate Immune Responses. J Immunol. Jul 7:ji2200942. doi: 10.4049/jimmunol.2200942. Epub ahead of print. PMID: 37417746
Related areas
All cell penetrating peptides >
All protein-protein interaction modulators >
All immunology research categories >
Technical Data
| Structure | H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Trp-Pro-Val-Ile-Leu-OH |
| Molecular Weight | 1989.23 |
| Formula | C85H152N40O16 |
| Sequence | RRRRRRRRGGWPVIL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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