Search
0
Items
Select
Search
MENU
Select

iSP2

Cat. No. PP-470

Structure:

H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Trp-Pro-Val-Ile-Leu-OH

Other Names:

STAP-2-derived synthetic peptide, R8-SP2-332/336, R8 STAP-2 C332/336

Activity:

STAP-2 - CD3zeta ITAM interaction blocker
Price Qty
1 mg    $ 165.00

iSP2 is a peptide derived from residues of signal-transducing adaptor protein-2 (STAP-2) identified as interacting with cluster of differentiation 3 zeta (CD3zeta) immunoreceptor tyrosine based activation motifs (ITAMs) conjugated to octa-arginine to enhance cell penetrating ability.  STAP-2 is an adaptor protein that positively regulates T-cell receptor (TCR) signaling by associating with TCR proximal CD3zeta ITAMs and lymphocyte-specific protein tyrosine kinase.  iSP2 directly interacts with the ITAM sequence and competitively inhibits STAP-2 - CD3zeta ITAMs interaction and decreases TCR activation in human and murine T cells.  In murine models of experimental autoimmune encephalomyelitis, iSP2 significantly suppresses disease development, to a similar extent to that seen in STAP-2 knockout mice.

Sasaki et al (2023) STAP-2-Derived Peptide Suppresses TCR-Mediated Signals to Initiate Immune Responses. J Immunol. Jul 7:ji2200942. doi: 10.4049/jimmunol.2200942. Epub ahead of print. PMID: 37417746


Related areas

All cell penetrating peptides >
All protein-protein interaction modulators >
All immunology research categories >


Technical Data

Structure H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Trp-Pro-Val-Ile-Leu-OH
Molecular Weight 1989.23
Formula C85H152N40O16
Sequence RRRRRRRRGGWPVIL
Modifications None

Solubility and Storage

Solubility Soluble in water
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by hplc

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com

USA and Canada

Tel: 610-994-1134

Toll Free: 855-FOCUS21 (855-362-8721)

Fax: 610-465-9100

sales@focusbiomolecules.com 


France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com


Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com


Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: info@abyntek.com


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: sale3@78bio.com

India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email:  globalbusiness1@namiki-s.co.jp


All distributors >