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Products
Pharmacology
Type
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- Technical support
- Resources
NP1
Cat. No. PP-460
Structure:
H-Phe-Leu-Pro-Ala-Ala-Ile-Cys*-Leu-Val-Ile-Lys-Thr-Cys*, disulphide bridge between cysteines 7 and 13
Other Names:
Neuroprotective Peptide 1
Activity:
Inhibits activation of the NF-κB pathway
NP1 was identified from a 60 amino acid residue precursor encoded by a 297-bp cDNA sequence from the skin of the amphibian frog Rana limnocharis. NP1 suppresses inflammation by reducing interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) levels, and also up-regulates expression of miR-6328, which in turn down regulates kappa B kinase β (IKKβ). IKKβ reduces phosphorylation of nuclear factor-kappa B p65 (NF- κB p65) and inhibits NF-κB (I-κB), inhibiting activation of the NF-κB pathway. In middle cerebral artery occlusion/reperfusion (MCAO/R) rats, NP1 reduces the volume of cerebral infarction and relieves neurological dysfunction. NP1 can also significantly alleviate the decrease in viability and increase in apoptosis of neuron like PC12 cells induced by oxygen glucose deprivation/re-oxygenation (OGD/R).
Li et al (2023) A short peptide exerts neuroprotective effects on cerebral ischemia-reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis. J Neuroinflammation 20(1) 53 PMID: 36855153
Related areas
All peptides >
All protein-protein interaction modulators >
All immunology research categories >
All neuroscience research categories >
Technical Data
| Structure | H-Phe-Leu-Pro-Ala-Ala-Ile-Cys*-Leu-Val-Ile-Lys-Thr-Cys*, disulphide bridge between cysteines 7 and 13 |
| Molecular Weight | C65H108N14O15S2 |
| Formula | 1389.8 |
| Sequence | FLPAAIC*LVIKTC* |
| Modifications | Disulphide bridge between cysteines 7 and 13 |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | > 95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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