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SHLP2
Cat. No. CK-050
Structure:
H-Met-Gly-Val-Lys-Phe-Phe-Thr-Leu-Ser-Thr-Arg-Phe-Phe-Pro-Ser-Val-Gln-Arg-Ala-Val-Pro-Leu-Trp-Thr-Asn-Ser-OH
Other Names:
Small humanin-like peptide 2
Activity:
Binds to and activates CXCR7
SHLP2 is one of six small humanin-like peptides (SHLP1 to 6) encoded by the 16S rRNA gene of the mitochondrial DNA genome, which is implicated in several biological processes such as aging and oxidative stress. SHLP2 induces β-Arrestin recruitment to CXCR7 with an EC50 of 0.9696 µM, and also binds directly to CXCR7, causing its internalization without affecting CXCR4. In vivo, administration of SHLP2 results in the suppression of food intake, activation of thermogenesis, and prevention of diet-induced obesity in mice. Activation of pro-opiomelanocortin (POMC) neurons by SHLP2 in the arcuate nucleus of the hypothalamus is involved in these processes. SHLP2 can also improve glucose tolerance and insulin sensitivity in vivo.
Cobb et al (2016) Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging 4 796 PMID: 27070352
Nashine and Kenney (2020) Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD. Cells 9(5) 1102 PMID: 32365540
Kim et al (2023) Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons. Nat Commun. 14(1) 4321 PMID: 37468558
Related areas
All peptides >
All chemokine receptor modulators >
All diabetes research categories >
All appetite regulation cateories >
Technical Data
| Structure | H-Met-Gly-Val-Lys-Phe-Phe-Thr-Leu-Ser-Thr-Arg-Phe-Phe-Pro-Ser-Val-Gln-Arg-Ala-Val-Pro-Leu-Trp-Thr-Asn-Ser-OH |
| Molecular Weight | 3015.58 |
| Formula | C142H214N36O35S |
| Sequence | MGVKFFTLSTRFFPSVQRAVPLWTNS |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
| Certificate of Analysis | CK-050-1MG SHLP2 CofA_669fb7ccf29d2.pdf |
| Safety Data Sheet | CK-050 SHLP2 SDS_669fb790d2430.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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