The product has been added to the cart.
By using our website, you agree to our use of cookies. find out more.
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
TAT-D1 peptide
Cat. No. DA-020
Structure:
H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Gln-Gly-Ser-Ser-Glu-Asp-Leu-Lys-Lys-Glu-Glu-Ala-Ala-Gly-Ile-Ala-Arg-Pro-Leu-OH
Other Names:
D1 peptide
Activity:
D1-D2 heteromer antagonist
Tat-D1 peptide is a peptide constructed from amino acids 396–413 of the dopamine D1 receptor C tail - a sequence chosen to include amino acids 404Glu and 405Glu whch were identified to interact with the dopamine D2 receptor - fused at the NH2 terminus to TAT peptide for cell permeability. TAT-D1 peptide blocks the interaction between D1 and D2 receptors, inhibiting D1-D2 heteromer expression and function without affecting other receptor oligomers such as D1-D1 homomers or D2-D5 heteromers. Tat-D1 peptide disruption of the D1-D2 heteromer abolishes its interaction with Gq and attenuates its calcium signalling and functions as a selective antagonist in vitro and in vivo. In animal models, TAT-D1 treatment alleviates behavioural despair symptoms and and exerts antidepressant-like effects in rats, and in addiction models the Tat-D1 peptide reverses SKF83959 induced inhibition of amphetamine sensitization.
Hasbi et al (2014) A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism. FASEB J. 11 4806 PMID: 25063849
Shen et al (2015) The dopamine D1-D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization. Pharmacol Biochem Behav. 128 33 PMID: 25444866
Andrianarivelo et al (2019) Modulation and functions of dopamine receptor heteromers in drugs of abuse-induced adaptations. Neuropharmacology 152 42 PMID: 30529032
Related areas
All cell penetrating peptides >
All dopamine receptor modulators >
All neuroscience research categories >
Technical Data
| Structure | H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Gln-Gly-Ser-Ser-Glu-Asp-Leu-Lys-Lys-Glu-Glu-Ala-Ala-Gly-Ile-Ala-Arg-Pro-Leu-OH |
| Molecular Weight | 3472.97 |
| Formula | C144H257N57O43 |
| Sequence | GRKKRRQRRRPQGSSEDLKKEEAAGIARPL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in saline |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
Contact Information
To place an order, or for customer services, order processing or technical support please contact us on:
UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com
USA and Canada
Tel: 610-994-1134
Toll Free: 855-FOCUS21 (855-362-8721)
Fax: 610-465-9100
France
CliniSciences
Tel : +33 9 77 40 09 09
Fax : +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com
Germany, Switzerland, Austria
BIOZOL Diagnostics
Tel: +49 (089) 3799 666-6
Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de
Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com
Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80
Fax: +34 94 404 80 81
Orders: info@abyntek.com
BIOHUB INTERNATIONAL
上海起发实验试剂有限公司
Tel: +86-15921799099
Tel: +86-021-50724187
Fax: +86-021-50724961
Orders: sale3@78bio.com
India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com
Japan
Namiki Shoji Co.
Tel：+81-050-5527-9850
Fax：+81-3-3352-2196
email: globalbusiness1@namiki-s.co.jp
Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
Learn moreContact us
Isca Biochemicals
26 Hanover Road
Exeter
EX1 2TL
(+44) 01392 422205
info@iscabiochemicals.com
© 2026 Isca Biochemicals. All rights reserved.
Designed and developed by tocostudio