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PDpep1.3
Cat. No. PP-430
Structure:
H-Asp-Glu-Glu-Ile-Glu-Arg-Gln-Leu-Lys-Ala-Leu-Gly-OH
Activity:
α-Synuclein-CHMP2B interaction disruptor
PDpep1.3 is a peptide optimised from a hit from a high-throughput screen to identify protein-protein interaction inhibitors that reduce α-synuclein oligomer levels and their associated cytotoxicity. PDpep1.3 disrupts the direct interaction between the C-terminal region of α-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B), a component of the endosomal sorting complex required for transport-III (ESCRT-III). α-Synuclein impedes endolysosomal activity via this interaction with CHMP2B, inhibiting its own degradation, and blockade of it with PDpep1.3 restores endolysosomal function and decreases α-synuclein levels in human cells. In vivo, PDpep1.3 protects dopaminergic neurons from α-synuclein-mediated degeneration in Parkinson’s disease models in rats.
Nim et al (2023) Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease. Nat Commun. 14(1) 2150 PMID: 37076542
Related areas
All peptides >
All protein-protein interaction modulators >
All dopaminergic modulators >
All neuroscience research categories >
Technical Data
| Structure | H-Asp-Glu-Glu-Ile-Glu-Arg-Gln-Leu-Lys-Ala-Leu-Gly-OH |
| Molecular Weight | 1399.73 |
| Formula | C59H101N17O22 |
| Sequence | DEEIERQLKALG |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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