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PDpep1.3

Cat. No. PP-430

Structure:

H-Asp-Glu-Glu-Ile-Glu-Arg-Gln-Leu-Lys-Ala-Leu-Gly-OH

Activity:

α-Synuclein-CHMP2B interaction disruptor
Price Qty
1 mg    $ 165.00

PDpep1.3 is a peptide optimised from a hit from a high-throughput screen to identify protein-protein interaction inhibitors that reduce α-synuclein oligomer levels and their associated cytotoxicity.  PDpep1.3 disrupts the direct interaction between the C-terminal region of α-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B), a component of the endosomal sorting complex required for transport-III (ESCRT-III).   α-Synuclein impedes endolysosomal activity via this interaction with CHMP2B, inhibiting its own degradation, and blockade of it with PDpep1.3 restores endolysosomal function and decreases α-synuclein levels in human cells.  In vivo, PDpep1.3 protects dopaminergic neurons from α-synuclein-mediated degeneration in Parkinson’s disease models in rats. 

Nim et al (2023) Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson's disease. Nat Commun. 14(1) 2150 PMID: 37076542


Related areas

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Technical Data

Structure H-Asp-Glu-Glu-Ile-Glu-Arg-Gln-Leu-Lys-Ala-Leu-Gly-OH
Molecular Weight 1399.73
Formula C59H101N17O22
Sequence DEEIERQLKALG
Modifications None

Solubility and Storage

Solubility Soluble in water
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by hplc

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