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- Technical support
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TAT-GluR6-9c
Cat. No. GL-170
Structure:
H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Leu-Pro-Gly-Lys-Glu-Thr-Met-Ala-OH
Other Names:
Tat-GluR6-9c
Activity:
GluR6-PSD95 interaction blocker
TAT-GluR6-9c is a peptide derived from the nine C terminal residues of the kainate receptor subunit GluR6, linked to the cell penetrating sequence TAT. TAT-GluR6-9c is able to perturb the interaction of GluR6 with postsynaptic density protein 95 (PSD-95) and suppress the assembly of the GluR6-PSD-95-mixed lineage protein kinase 3 (MLK3) signalling module, causing inhibition of c-Jun N-terminal kinase (JNK) activation. JNK has an important role during global and focal cerebral ischemia/reperfusion and consistent with JNK inhibition, TAT-GluR6-9c pretreatment decreases neuronal death induced by kainate in vitro. In vivo, TAT-GluR6-9c protects against kainate-induced epileptic seizure and has a neuroprotective effect against ischaemic brain damage, significantly decreasing neuronal degeneration.
Liu et al (2006) Neuroprotection of Tat-GluR6-9c against neuronal death induced by kainate in rat hippocampus via nuclear and non-nuclear pathways. J Biol Chem. 281(25) 17432 PMID: 16624817
Pei et al (2006) Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence. Brain 129(Pt 2) 465 PMID: 16330502
Meloni et al (2020) Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action. Front Neurol. 11 108 PMID: 32158425
Related areas
All cell penetrating peptides >
All protein-protein interaction modulators >
All ionotropic glutamate receptor modulators >
All neuroscience research categories >
Technical Data
| Structure | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Leu-Pro-Gly-Lys-Glu-Thr-Met-Ala-OH |
| Molecular Weight | 2542.47 |
| Formula | C106H191N45O26S |
| Sequence | YGRKKRRQRRRRLPGKETMA |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in saline |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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