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Pharmacology
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- Technical support
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KGYY15
Cat. No. PP-410
Structure:
H-Val-Leu-Gln-Trp-Ala-Lys-Lys-Gly-Tyr-Tyr-Thr-Met-Lys-Ser-Asn-OH
Other Names:
Mouse KGYY15, KGYY15 peptide
Activity:
Interacts with CD40
KGYY15 is a peptide derived from amino acids 136 to 150 of the mouse protein CD154, a region determined from crystallography and site-directed mutational analysis to interact with CD40, the type I transmembrane protein found on antigen-presenting cells. CD154 is primarily expressed on activated T cells and CD40 - CD154 interactions are critical in the development and perpetuation of autoimmune disease, making CD40 signaling a target in autoimmunity. In addition to interacting with CD40, KGYY15 interacts with the integrins CD11a/CD18 and CD11b/CD18, and the resulting modulation of CD40-CD154 signalling may be more advantageous than complete inhibition. In vivo, KGYY15 is highly efficient in preventing hyperglycaemia in NOD mice that spontaneously develop type 1 diabetes. KGYY15 can also reverse new-onset hyperglycaemia.
Vaitaitis et al (2014) A CD40-targeted peptide controls and reverses type 1 diabetes in NOD mice. Diabetologia 57(11) 2366 PMID: 25104468
Vaitaitis et al (2019) CD40-targeted peptide proposed for type 1 diabetes therapy lacks relevant binding affinity to its cognate receptor. Reply to Pagni PP, Wolf A, Lo Conte M et al. Diabetologia 62(9) 1730 PMID: 31286154
Vaitaitis and Wagner (2023) Modulating CD40 and integrin signaling in the proinflammatory nexus using a 15-amino-acid peptide, KGYY15. J Biol Chem. 299(5) 104625 PMID: 36944397
Related areas
All peptides >
All protein-protein interaction modulators >
All integrin receptor modulators >
All diabetes research categories >
All immunology research categories >
Technical Data
| Structure | H-Val-Leu-Gln-Trp-Ala-Lys-Lys-Gly-Tyr-Tyr-Thr-Met-Lys-Ser-Asn-OH |
| Molecular Weight | 1815.93 |
| Formula | C84H129N21O22S |
| Sequence | VLQWAKKGYYTMKSN |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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