The product has been added to the cart.
By using our website, you agree to our use of cookies. find out more.
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
Stalk peptide
Cat. No. AC-030
Structure:
H-Thr-Ser-Phe-Ser-Ile-Leu-Met-Ser-Pro-Asn-OH
Activity:
GPR110 activator
Stalk peptide is a fragment of the N-terminal region of the adhesion G protein-coupled receptor (aGPCR) GPR110, which in common with the general activation mechanism of aGPCRs is generated by an autoproteolysis process, after which it activates the receptor by the tethered stalk peptide mechanism. GPR110, also known as ADGRF1, is an aGPCR that plays a key role in neurite growth and synaptogenesis in cortical neurons, and addition of stalk peptide to a culture of neurons isolated from mouse brain promotes neurite outgrowth similarly to the effect of the endogenous GPR110 ligand docosahexaenoic acid, suggesting that GPR110 is activated through the stalk peptide mechanism under physiological conditions.
Zhu et al (2022) Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling. Nat Commun. 13(1) 5513 PMID: 36127364
Related areas
All peptides >
All adhesion class receptor modulators >
All immunology research categories >
Technical Data
| Structure | H-Thr-Ser-Phe-Ser-Ile-Leu-Met-Ser-Pro-Asn-OH |
| Molecular Weight | 1095.53 |
| Formula | C48H77N11O16S |
| Sequence | TSFSILMSPN |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
Contact Information
To place an order, or for customer services, order processing or technical support please contact us on:
UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com
USA and Canada
Tel: 610-994-1134
Toll Free: 855-FOCUS21 (855-362-8721)
Fax: 610-465-9100
France
CliniSciences
Tel : +33 9 77 40 09 09
Fax : +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com
Germany, Switzerland, Austria
BIOZOL Diagnostics
Tel: +49 (089) 3799 666-6
Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de
Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com
Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80
Fax: +34 94 404 80 81
Orders: info@abyntek.com
BIOHUB INTERNATIONAL
上海起发实验试剂有限公司
Tel: +86-15921799099
Tel: +86-021-50724187
Fax: +86-021-50724961
Orders: sale3@78bio.com
India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com
Japan
Namiki Shoji Co.
Tel：+81-050-5527-9850
Fax：+81-3-3352-2196
email: globalbusiness1@namiki-s.co.jp
Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
Learn moreContact us
Isca Biochemicals
26 Hanover Road
Exeter
EX1 2TL
(+44) 01392 422205
info@iscabiochemicals.com
© 2025 Isca Biochemicals. All rights reserved.
Designed and developed by tocostudio