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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
Catestatin (human)
Cat. No. NA-020
Structure:
H-Ser-Ser-Met-Lys-Leu-Ser-Phe-Arg-Ala-Arg-Ala-Tyr-Gly-Phe-Arg-Gly-Pro-Gly-Pro-Gln-Leu-OH
Other Names:
Human chromogranin A(352-372), CST, hCgA352−372
Activity:
Inhibits nicotine induced catecholamine release
Catestatin (human) is a neuroendocrine peptide that is derived from proteolytic cleavage of the precursor chromogranin A, corresponding to fragments 352-372 of human chromogranin A. Catestatin (human) was first identified as a potent inhibitor of nicotine induced catecholamine release and as it is secreted together with catecholamines, it can function as an autocrine negative feedback-loop. Catestatin (human) also plays a role in the regulation of hypertension and cardiac function, as well as in promoting angiogenesis, decreasing obesity and regulating innate immunity.
Taylor et al (2000) Formation of the catecholamine release-inhibitory peptide catestatin from chromogranin A. Determination of proteolytic cleavage sites in hormone storage granules. J Biol Chem. 275(30) 22905 PMID: 10781584
Muntjewerff (2018) Catestatin as a Target for Treatment of Inflammatory Diseases. Front Immunol. 9 2199 PMID: 3033792
Zalewska et al (2022) Role of Catestatin in the Cardiovascular System and Metabolic Disorders. Front Cardiovasc Med. 9 909480 PMID: 356652
González-Dávila et al (2022) Catestatin selects for colonization of antimicrobial-resistant gut bacterial communities. ISME J. 16(8) 1873 PMID: 35440728
All antimicrobial peptides >
All nicotinic acetylcholine receptor modulators >
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Technical Data
| Structure | H-Ser-Ser-Met-Lys-Leu-Ser-Phe-Arg-Ala-Arg-Ala-Tyr-Gly-Phe-Arg-Gly-Pro-Gly-Pro-Gln-Leu-OH |
| CAS Number | 197151-46-5 |
| Molecular Weight | 2325.22 |
| Formula | C104H164N32O27S |
| Sequence | SSMKLSFRARAYGFRGPGPQL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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