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ssK36
Cat. No. SP-010
Structure:
H-Ala-Pro-Arg-Phe-Gly-Gly-Val-Lys-Arg-Pro-Asn-Arg-Tyr-Arg-Pro-OH
Other Names:
ssK36 (29–43)
Activity:
SET domain containing protein 2 (SETD2) super substrate
ssK36, or ssK36 (29–43), is a SET-domain containing protein 2 (SETD2) super substrate. SETD2, also called KMT3A, was first identified as huntingtin interacting protein 1 (HYPB, HIP-1) and can add up to three methyl groups to K36 of histone H39 (H3K36). ssK36 (29-43 has been derived from the currently used SETD2 substrate peptide H3K36 (29-43) but is methylated about 290-fold faster, making it a super substrate. The increased methylation of ssK36 is due to an increase in the rate of catalysis and only to a smaller degree to improved binding.
Schuhmacher et al (2020) Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate. Commun. Biol. 3(1) 511 PMID: 32939018
Related areas
All substrate peptides >
All epigenetic research categories >
Technical Data
| Structure | H-Ala-Pro-Arg-Phe-Gly-Gly-Val-Lys-Arg-Pro-Asn-Arg-Tyr-Arg-Pro-OH |
| Molecular Weight | 1771 |
| Formula | C79H127N29O18 |
| Sequence | APRFGGVKRPNRYRP |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water and physiological buffers |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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