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- Resources
Rice-memolin
Cat. No. NA-010
Structure:
H-Val-Tyr-Thr-Pro-Gly-OH
Other Names:
VYTPG
Activity:
Rice derived peptide able to improve cognitive decline
Rice-memolin is a peptide generated by thermolysin digestion of rice bran that can improve cognitive decline. Rice-memolin corresponds to fragments of three rice protein sequences and appears to be resistant to gut proteases. In male ddY mice, rice-memolin improves cognitive decline induced by short-term high fat diet intake after oral administration in two behaviour tests, an effect inhibited by injection of methyllycaconitine (MLA), suggesting that rice-memolin acts through α7nAChR nicotinic receptors. Rice‑memolin also increases neurogenesis and expression of neurotrophic factors in the hippocampus and reduces blood glucose. Rice-memolin has no effect on hippocampal mRNA expression of inflammatory cytokines such as tumour necrosis factor-α, interleukin (IL)-1α, IL-1β, and IL-6. Rice-memolin is the first rice-bran-derived peptide able to improve cognitive decline.
Shobako et al (2023) Rice-memolin, a novel peptide derived from rice bran, improves cognitive function after oral administration in mice. Sci Rep. 13(1) 2887 PMID: 36807368
Related areas
All peptides >
All nicotinic receptor modulators >
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Technical Data
| Structure | H-Val-Tyr-Thr-Pro-Gly-OH |
| Molecular Weight | 535.26 |
| Formula | C25H37N5O8 |
| Sequence | VYTPG |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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