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Products
Pharmacology
Type
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- Technical support
- Resources
VnP-16
Cat. No. IG-060
Structure:
H-Arg-Val-Tyr-Phe-Phe-Lys-Gly-Lys-Gln-Tyr-Trp-Glu-NH2
Other Names:
Vitronectin derived bioactive peptide
Activity:
β1 and αvβ3 integrin signaling modulator
VnP-16 is a peptide corresponding to residues 270–281 of human vitronectin, which exerts an anti-osteoporotic effect via β1 and αvβ3 integrin signaling. VnP-16 promotes bone formation by accelerating osteoblast differentiation through direct interaction with β1 integrin followed by FAK activation, while inhibiting bone resorption through restraint of JNK-c-Fos-NFATc1 induced osteoclast differentiation and αvβ3 integrin-c-Src-PYK2 mediated resorption. In a mouse model of estrogen deficiency induced osteoporosis, VnP-16 reverses ovariectomy induced bone loss by increasing osteoblast differentiation and promoting bone formation, while decreasing osteoclastogenesis and inhibiting bone resorption.
Min et al (2018) A vitronectin-derived peptide reverses ovariectomy-induced bone loss via regulation of osteoblast and osteoclast differentiation. Cell Death Differ. 25(2) 268 PMID: 28937683
Min et al (2022) Vitronectin-derived bioactive peptide prevents spondyloarthritis by modulating Th17/Treg imbalance in mice with curdlan-induced spondyloarthritis. PLoS One 17(1) e0262183 PMID: 34986165
Kang et al (2022) A Vitronectin-Derived Peptide Restores Ovariectomy-Induced Bone Loss by Dual Regulation of Bone Remodeling. Tissue Eng Regen Med. Oct 7 doi: 10.1007/s13770-022-00486-w. Epub ahead of print. PMID: 36207661
Related areas
All peptides >
All integrin receptor modulators >
All immunology research categories >
Technical Data
| Structure | H-Arg-Val-Tyr-Phe-Phe-Lys-Gly-Lys-Gln-Tyr-Trp-Glu-NH2 |
| Molecular Weight | 1648.85 |
| Formula | C82H112N20O17 |
| Sequence | RVYFFKGKQYWE-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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