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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
SMRwt
Cat. No. PP-360
Structure:
H-Val-Gly-Phe-Pro-Val-Ala-Ala-Val-Gly-Phe-Pro-Val-Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys-OH
Other Names:
Secretion modification region peptide, SMR peptide, Wildtype-3
Activity:
Disrupts the Nef-mortalin interaction, anti-metastatic
SMRwt is derived from the secretion modification region (SMR, amino acids 66 to 70) of the HIV-1 Nef protein. Nef is a 27-kDa protein produced early during HIV infection of a cell, which interacts with mortalin, a member of the heat shock 70-kDa protein family via Nef's SMR motif, an interaction which is disrupted by the SMRwt peptide. In breast cancer cells SMRwt interacts with mortalin and also the structural protein vimentin to inhibit pro-epithelial-mesenchymal transition (EMT) exosome release, and induce EMT tumour suppressor protein expression. Exosomes containing EMT programs transmit pro-metastatic phenotypes and SMRwt peptide treatment results in an effective blockade of breast cancer cell migration.
Shelton et al (2012) Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release. J Virol. 86(1) 406 PMID: 22013042
Huang et al (2017) Secretion modification region-derived peptide blocks exosome release and mediates cell cycle arrest in breast cancer cells. Oncotarget 8(7) 11302 PMID: 28076321
Huang et al (2022) Novel secretion modification region (SMR) peptide exhibits anti-metastatic properties in human breast cancer cells. Sci Rep. 12(1) 13204 PMID: 35915218
Related areas
All peptides >
All protein-protein interaction modulators >
All cancer research categories >
Technical Data
| Structure | H-Val-Gly-Phe-Pro-Val-Ala-Ala-Val-Gly-Phe-Pro-Val-Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys-OH |
| Molecular Weight | 2153.03 |
| Formula | C99H144N22O32 |
| Sequence | VGFPVAAVGFPVDYKDDDDK |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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