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Products
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KLA peptide
Cat. No. AM-340
Structure:
H-Lys-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Lys-NH2
Other Names:
(KLAKLAK)2, KLA, Proapoptotic peptide
Activity:
Proapoptotic mitochondrial membrane disruptor
KLA peptide is an antimicrobial peptide with an amphipathic alpha-helical structure and the ability to disrupt mitochondrial membranes. KLA is an important anti-cancer peptide but has poor eukaryotic cell penetrating ability, and consequently requires the assistance of other cell penetrating peptides for effective translocation. Once KLA peptide is internalized into eukaryotic cells, it can destroy mitochondrial membranes and initiate the tumour cell apoptosis process, and many strategies have been employed to facilitate this. KLA peptide exhibits cytotoxicity against human breast cancer and other tumour cells in vivo, slowing tumour growth and extending survival time.
Javadpour et al (1996) De novo antimicrobial peptides with low mammalian cell toxicity. J Med Chem. 39(16) 3107 PMID: 8759631
Jäkel et al (2012) Efficacy of a proapoptotic peptide towards cancer cells. In Vivo 26(3) 419 PMID: 22523294
Permpoon et al (2020) Inhibition of Tumor Growth against Chemoresistant Cholangiocarcinoma by a Proapoptotic Peptide Targeting Interleukin-4 Receptor. Mol Pharm. 17(11) 4077 PMID: 32881535
Related areas
All antimicrobial peptides >
All regulated cell death research areas >
All cancer research areas >
Technical Data
| Structure | H-Lys-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Lys-NH2 |
| CAS Number | 180461-53-4 |
| Molecular Weight | 1522.08 |
| Formula | C72H139N21O14 |
| Sequence | KLAKLAKKLAKLAK-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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