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RS17
Cat. No. PP-330
Structure:
H-Arg-Arg-Tyr-Lys-Gln-Asp-Gly-Gly-Trp-Ser-His-Trp-Ser-Pro-Trp-Ser-Ser-NH2
Activity:
CD47 - SIRPα signalling inhibitor
RS17 is a peptide which binds to the transmembrane protein CD47 and blocks the interaction of CD47 with the regulatory membrane glycoprotein signal regulatory protein α (SIRPα). In normal cells, CD47 interaction with SIRPα on the macrophage surface membrane sends a phagocytosis inhibiting signal, a mechanism which can be taken advantage of by cancer cells to enable immune escape. RS17 blockade of the CD47 and SIRPα interaction in cancer cells can prevent phagocytosis evasion, and treatment with RS17 significantly promotes the removal of tumour cells by macrophages. RS17 has a strongly inhibitory effect on tumour growth in a cancer xenograft mouse model.
Wang et al (2021) An antitumor peptide RS17-targeted CD47, design, synthesis, and antitumor activity. Cancer Med. 10(6) 2125 PMID: 33629544
Related areas
All peptides >
All protein-protein interaction modulators >
All cancer research categories >
All regulated cell death research categories >
Technical Data
| Structure | H-Arg-Arg-Tyr-Lys-Gln-Asp-Gly-Gly-Trp-Ser-His-Trp-Ser-Pro-Trp-Ser-Ser-NH2 |
| Molecular Weight | 2119.28 |
| Formula | C96H131N31O25 |
| Sequence | RRYKQDGGWSHWSPWSS-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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