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Products
Pharmacology
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- Technical support
- Resources
SAP15
Cat. No. HD-010
Structure:
H-Gly-Lys-Cys-Ser-Thr-Arg-Gly-Arg-Lys-Cys-Cys-Arg-Arg-Lys-Lys-OH
Other Names:
Peptide 3
Activity:
HDAC5 inhibitor
SAP15 is a cell penetrating peptide corresponding to the last 15 amino acids of the host defense
peptide human β-defensin 3, which is involved in adaptive immunity and pro- and anti-inflammatory responses. SAP15 is a histone deacetylase 5 (HDAC5) inhibitor with a dissociation constant of 86 nM in an SPR assay and inhibits lipopolysaccharide (LPS) induced phosphorylation of intracellular HDAC5 and
NF-κB p65 in murine macrophages. In vivo, subcutaneous injection of SAP15-loaded sodium hyaluronic acid
solution significantly decreases hind paw swelling, joint inflammation, and
serum cytokine levels in a collagen induced arthritis (CIA) rat model.
Lee et al (2021) Engineered synthetic cell penetrating peptide with intracellular anti-inflammatory bioactivity: An in vitro and in vivo study. J Biomed Mater Res A. 109(10) 2001 PMID: 33818867
Related areas
All antimicrobial peptides>
All immunology categories >
All histone deacetylase modulators >
Technical Data
| Structure | H-Gly-Lys-Cys-Ser-Thr-Arg-Gly-Arg-Lys-Cys-Cys-Arg-Arg-Lys-Lys-OH |
| Molecular Weight | 1767.18 |
| Formula | C68 H131N31O18S3 |
| Sequence | GKCSTRGRKCCRRKK |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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