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Products
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NP-12
Cat. No. PP-300
Structure:
H-Ser-Asn-Thr-Ser-Glu-Ser-Phe-Lys(H-Ser-Asn-Thr-Ser-Glu-Ser-Phe)-Phe-Arg-Val-Thr-Gln-Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-NH2
Other Names:
AUNP 12, AUR 012, PD-1–derived peptide
Activity:
PD-1 - PD-L1 interaction blocker
NP-12 is a branched peptide designed from analysis of the strands and loops of programmed cell death protein 1 (PD-1) at the interface of the PD-1/ programmed cell death ligand 1 (PD-L1) interaction. NP-12 binds to PD-L1 and is a functional equipotent antagonist of both PD-L1 and PD-L2 signaling. In preclinical models of melanoma, colon
cancer, and kidney cancers, NP-12 showed significant efficacy
in inhibiting primary tumour growth and metastasis. NP-12 shows antitumour activity in pre-established tumour models
either as a single agent or when in combination with other immunologic cell death agents.
Sasikumar et al (2019 A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy. Mol Cancer Ther. 18(6) 1081 PMID: 31015307
Related areas
All peptides >
All protein-protein interaction modulators >
All cancer research areas >
Technical Data
| Structure | H-Ser-Asn-Thr-Ser-Glu-Ser-Phe-Lys(H-Ser-Asn-Thr-Ser-Glu-Ser-Phe)-Phe-Arg-Val-Thr-Gln-Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-NH2 |
| CAS Number | 1353563-85-5 |
| Molecular Weight | 3261.55 |
| Formula | C142H226N40O48 |
| Sequence | SNTSESF-K(SNTSESF)-FRVTQLAPKAQIKE-NH2 |
| Modifications | C terminal amide, amide bridge between Lys-8 and Phe-7 in branch chain |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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