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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
KP1
Cat. No. PP-290
Structure:
H-Phe-Gln-Gly-Thr-Phe-Pro-Asp-Gly-Phe-Leu-Trp-Ala-Val-Gly-Ser-Ala-Ala-Tyr-Gln-Thr-Glu-Gly-Gly-Trp-Gln-Gln-His-Gly-Lys-Gly-OH
Other Names:
KP1 (human), Klotho-derived peptide 1
Activity:
Disrupts TGF-β/TβR2 interaction
KP1 is a peptide representing the sequence Phe57 to Lys86 of the anti aging protein Klotho, and is one of the buried β-strands in the N-terminal domain. KP1 mimics the anti-fibrotic action of Klotho by constraining TGF-β signaling, KP1 acts through binding to TGF-β receptor 2 (TβR2) and disrupting TGF-β/TβR2 interaction. KP1 inhibits multiple downstream TGF-β pathways including activation of Smad2/3 and mitogen activated protein kinases. In mouse models of renal fibrosis, KP1 preserves kidney function, ameliorates renal fibrosis and restores endogenous Klotho expression.
Yuan (2022) A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling. Nat Commun. 13(1) 438 PMID: 35064106
Related areas
All peptides >
All protein-protein interaction modulators >
All immunology research areas >
Technical Data
| Structure | H-Phe-Gln-Gly-Thr-Phe-Pro-Asp-Gly-Phe-Leu-Trp-Ala-Val-Gly-Ser-Ala-Ala-Tyr-Gln-Thr-Glu-Gly-Gly-Trp-Gln-Gln-His-Gly-Lys-Gly-OH |
| Molecular Weight | 3228.48 |
| Formula | C149H203N39O43 |
| Sequence | FQGTFPDGFLWAVGSAAYQTEGGWQQHGKG |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water to 1 mg/ml |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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