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SHBG141–161
Cat. No. OR-030
Structure:
H-Ile-Ala-Leu-Gly-Gly-Leu-Leu-Phe-Pro-Ala-Ser-Asn-Leu-Arg-Leu-Pro-Leu-Val-Pro-Ala-Leu-OH
Other Names:
SHBG(141–161) domain peptide, SHBG(141–161)
Activity:
GPRC6A agonist
SHBG141–161 is a peptide corresponding to amino acids 141–161 of sex hormone binding globulin (SHBG), the loop region of SHBG connecting β-strands 11 and 12. SHBG141–161 is an agonist of the class C orphan G protein coupled receptor GPRC6A, a major regulator of energy metabolism and male fertility, and SHBG141-161 competes for binding to it with its endogenous ligand undercarboxylated osteocalcin (ucOCN). In vitro, SHBG141-161 stimulates insulin secretion from β-cells and also the production and release of testosterone from Leydig and Langerhans β-cells cell lines.
De Toni et al (2019) SHBG141-161 Domain-Peptide Stimulates GPRC6A-Mediated Response in Leydig and β-Langerhans cell lines. Sci Rep. 9(1) 19432 PMID: 31857654
Related areas
All peptides >
All orphan 7-TM receptor modulators >
All endocrinology areas >
All metabolism areas >
Technical Data
| Structure | H-Ile-Ala-Leu-Gly-Gly-Leu-Leu-Phe-Pro-Ala-Ser-Asn-Leu-Arg-Leu-Pro-Leu-Val-Pro-Ala-Leu-OH |
| Molecular Weight | 2145.66 |
| Formula | C103H173N25O24 |
| Sequence | IALGGLLFPASNLRLPLVPAL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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