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Products
Pharmacology
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- Technical support
- Resources
S9pep
Cat. No. NR-180
Structure:
H-Ala-Asp-Ser-Pro-His-Ser-Ser-Ser-Gly-Met-Ser-Glu-Val-His-Ser-Pro-Gly-Glu-His-Ser-Gly-OH
Other Names:
SOX9(208-229)
Activity:
SOX9 mimetic
S9pep is a short sequence of the transcription factor SOX-9, located at the hinge between the high mobility group (HMG) - DNA-binding domain and the SOX-E central conserved domain, that can mimic SOX9 tumour suppressive properties. Like full length SOX9, S9pep inhibits Wnt/β-catenin signaling and the expression of c-Myc, its oncogenic target gene, by relocating β-catenin from the chromatin to the cytosol. S9pep disrupts colorectal cancer cell morphology, reduces the growth of colorectal cancer cells and stem cells, and inhibits tumour development in vivo.
Blache et al (2019) A Short SOX9 Peptide Mimics SOX9 Tumor Suppressor Activity and Is Sufficient to Inhibit Colon Cancer Cell Growth. Mol Cancer Ther. 2019 18(8) 1386 PMID: 31092563
Related areas
All peptides >
All nuclear receptor modulators >
All cancer research categories >
All stem cell categories >
Technical Data
| Structure | H-Ala-Asp-Ser-Pro-His-Ser-Ser-Ser-Gly-Met-Ser-Glu-Val-His-Ser-Pro-Gly-Glu-His-Ser-Gly-OH |
| Molecular Weight | 2079.10 |
| Formula | C82H123N27O35S |
| Sequence | ADSPHSSSGMSEVHSPGEHSG |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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