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Fz7-21

Cat. No. FZ-010

Structure:

Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val- Met-Tyr-NH2

Other Names:

FZD7-binding peptide

Activity:

Selective FZD7 antagonist
Price Qty
1 mg    $ 149.00

Fz7-21 is a peptide identified from a phage library that impairs the function of Frizzled 7 (FZD7) in Wnt–β-catenin signalling, binding to the FZD7 extracellular cysteine rich domain (CRD) and altering its conformation and the architecture of its lipid-binding groove.  Fz7-21 antagonises Wnt–β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A with an IC50 of 100 nM and also blocks WNT3A-mediated stabilization of β -catenin in mouse L cells.  FzD7-21 impairs stem cell function in intestinal organoids.

Nile et al (2018) A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 14(6) 582 PMID: 29632413


Related data

All frizzled receptor modulators >
All stem cell categories >


Technical Data

Structure Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val- Met-Tyr-NH2
CAS Number 2247635-23-8
Molecular Weight 1796.05
Formula C83H114N18O23S2
Sequence Ac-LPSDDLEFWCHVMY-NH2
Modifications N terminal acetyl, C terminal amide

Solubility and Storage

Solubility Soluble in DMSO
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by hplc

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205Fax: (+44) 01392 279510
[email protected]

USA and Canada

Tel: 610-994-1134

Toll Free: 855-FOCUS21 (855-362-8721)

Fax: 610-465-9100

[email protected] 


France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
Orders and customer support : [email protected]ciences.com


Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: [email protected]


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: [email protected]


Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: [email protected]


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: [email protected]

India
Biotechno Labs
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: [email protected]


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email: [email protected]


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