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Fz7-21
Cat. No. FZ-010
Structure:
Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val- Met-Tyr-NH2
Other Names:
FZD7-binding peptide
Activity:
Selective FZD7 antagonist
Fz7-21 is a peptide identified from a phage library that impairs the function of Frizzled 7 (FZD7) in Wnt–β-catenin signalling, binding to the FZD7 extracellular cysteine rich domain (CRD) and altering its conformation
and the architecture of its lipid-binding groove. Fz7-21 antagonises Wnt–β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A with an IC50 of 100 nM and also blocks WNT3A-mediated stabilization of β -catenin in
mouse L cells. FzD7-21 impairs stem cell function in intestinal organoids.
Nile et al (2018) A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 14(6) 582 PMID: 29632413
Related data
All peptides >
All frizzled receptor modulators >
All stem cell categories >
Technical Data
| Structure | Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val- Met-Tyr-NH2 |
| CAS Number | 2247635-23-8 |
| Molecular Weight | 1796.05 |
| Formula | C83H114N18O23S2 |
| Sequence | Ac-LPSDDLEFWCHVMY-NH2 |
| Modifications | N terminal acetyl, C terminal amide |
Solubility and Storage
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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