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Products
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S7
Cat. No. CY-020
Structure:
H-Leu-Ser-Leu-Ile-Thr-Arg-Leu-OH
Other Names:
Peptide L, pepL, S7 peptide
Activity:
Interleukin-6 inhibitor
S7 is a peptide identified from a phage display library, which selectively binds to the interleukin-6 receptor (IL-6R) alpha chain (gp80) and inhibits IL-6 mediated events. S7 can inhibit IL-6 induced VEGF-A expression and angiogenesis in different cancer cell lines, and can prevent IL-6 mediated survival signalling and sensitise cervical cancer cells to chemotherapy. S7 is bioavailable in vivo, and can induce apoptopic cell death and suppress IL-6 induced tumour growth in mouse models.
Su et al (2005) A novel peptide specifically binding to interleukin-6 receptor (gp80) inhibits angiogenesis and tumor growth. Cancer Res. 65(11) 4827 PMID: 15930303
Figueiredo et al (2020) Ligand-Mediated Targeting of Cytokine Interleukin-27 Enhances Its Bioactivity In Vivo. Mol. Ther. Methods Clin. Dev. 17 739 PMID: 32346551
Figueiredo et al (2021) Reengineering Tumor Microenvironment with Sequential Interleukin Delivery. Bioengineering 8(7) 90 PMID: 34209203
Related data
All peptides >
All cytokine receptor modulators >
All cancer research categories >
All immunology categories >
Technical Data
| Structure | H-Leu-Ser-Leu-Ile-Thr-Arg-Leu-OH |
| Molecular Weight | 815.02 |
| Formula | C37H70N10O10 |
| Sequence | LSLITRL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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