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A11

Cat. No. PP-250

Structure:

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Tyr-Val-Gln-Thr-Val-Lys-Ser-Ser-Lys-Gly-OH

Other Names:

ANXA1-derived 11 amino acid–long peptide

Activity:

ANXA1–EphA2 interaction blocker
Price Qty
1 mg    $ 215.00

A11 is a peptide derived from amino acid residues 20-30 of the ANXA1 N-terminus fused to the cell penetrating peptide CPP.  A11 blocks ANXA1 competition with the E3 ubiquitin ligase Cbl for binding EphA2, enhancing Cbl-mediated EphA2 ubiquitination and degradation, and reducing the oncogenic mechanism of the ANXA1– EphA2 interaction in nasopharyngeal carcinoma (NPC).  A11 can suppress NPC cell growth in vitro and in vivo.  

Feng et al (2020) ANXA1 Binds and Stabilizes EphA2 to Promote Nasopharyngeal Carcinoma Growth and Metastasis. Cancer Res. 80(20) 4386 PMID: 32737118


Related categories

All protein-protein interaction modulators >
All cancer research categories >
All ubiquitin-proteasome system categories >


Technical Data

Structure H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Tyr-Val-Gln-Thr-Val-Lys-Ser-Ser-Lys-Gly-OH
Molecular Weight 2767.19
Formula C117H204N46O32
Sequence YGRKKRRQRRREYVQTVKSSKG
Modifications None

Solubility and Storage

Solubility Soluble in water
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by hplc

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205Fax: (+44) 01392 279510
[email protected]

USA and Canada

Tel: 610-994-1134

Toll Free: 855-FOCUS21 (855-362-8721)

Fax: 610-465-9100

[email protected] 


France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
Orders and customer support : [email protected]


Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: [email protected]


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: [email protected]


Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: [email protected]


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: [email protected]

India
Biotechno Labs
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: [email protected]


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email: [email protected]


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