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Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
A11
Cat. No. PP-250
Structure:
H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Tyr-Val-Gln-Thr-Val-Lys-Ser-Ser-Lys-Gly-OH
Other Names:
ANXA1-derived 11 amino acid–long peptide
Activity:
ANXA1–EphA2 interaction blocker
A11 is a peptide derived from amino acid residues 20-30 of the ANXA1 N-terminus fused to the cell penetrating peptide CPP. A11
blocks ANXA1 competition with the E3 ubiquitin ligase Cbl for binding EphA2, enhancing Cbl-mediated EphA2 ubiquitination and degradation, and reducing the oncogenic
mechanism of the ANXA1– EphA2 interaction in nasopharyngeal carcinoma (NPC). A11 can suppress NPC cell growth in vitro and in vivo.
Feng et al (2020) ANXA1 Binds and Stabilizes EphA2 to Promote Nasopharyngeal Carcinoma Growth and Metastasis. Cancer Res. 80(20) 4386 PMID: 32737118
Related categories
All cell penetrating peptides >
All protein-protein interaction modulators >
All cancer research categories >
All ubiquitin-proteasome system categories >
Technical Data
| Structure | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Tyr-Val-Gln-Thr-Val-Lys-Ser-Ser-Lys-Gly-OH |
| Molecular Weight | 2767.19 |
| Formula | C117H204N46O32 |
| Sequence | YGRKKRRQRRREYVQTVKSSKG |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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