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Orexin A (human, rat, mouse)

Cat. No. OX-050

Structure:

Glp-Pro-Leu-Pro-Asp-*Cys-*Cys-Arg-Gln-Lys-Thr-*Cys-Ser-*Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (*disulphide bridges between cysteines 6 and 12, and cysteines 7 and 14)

Other Names:

Hypocretin 1

Activity:

Endogenous OX1 and OX2 orexin receptor agonist
Price Qty
0.5 mg    $ 189.00

Orexin A (human, rat, mouse) is an endogenous agonist at orexin receptors with Ki values of 20 and 38 nM for OX1 and OX2 receptors respectively.  Orexin A stimulates feeding following central administration and is involved in other hypothalamic functions, influencing wakefulness by affecting dopamine, norepinephrine, histamine and acetylcholine systems to stabilize sleep cycles.   An absence of orexin A causes narcolepsy, and in animal models, it can alleviate cognitive deficits caused by loss of sleep.

Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573 PMID: 9491897

Deadwyler et al (2007) Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates. J Neurosci. 27(52) 14239 PMID: 18160631

Sakurai (2014) The role of orexin in motivated behaviours. Nat Rev Neurosci. 15(11) 719 PMID: 25301357

Guide to Pharmacology - Orexin A


Related areas

All peptides >
All orexin receptor modulators >
All neuroscience categories >
All endocrinology categories >
All appetite regulation categories >


Technical Data

Structure Glp-Pro-Leu-Pro-Asp-*Cys-*Cys-Arg-Gln-Lys-Thr-*Cys-Ser-*Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (*disulphide bridges between cysteines 6 and 12, and cysteines 7 and 14)
CAS Number 205640-90-0
Molecular Weight 3561.12
Formula C152H243N47O44S4
Sequence XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2
Modifications X is Glp, disulphide bridges between cysteines 6 and 12 and cysteines 7 and 14, C-terminal amide

Solubility and Storage

Solubility Soluble to 1 mg/ml in water
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by hplc

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