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Orexin A (human, rat, mouse)
Cat. No. OX-050
Structure:
Other Names:
Activity:
Orexin A (human, rat, mouse) is an endogenous agonist at orexin receptors with Ki values of 20 and 38 nM for OX1 and OX2 receptors respectively. Orexin A stimulates feeding following central administration and is involved in other hypothalamic functions, influencing wakefulness by affecting dopamine, norepinephrine, histamine and acetylcholine systems to stabilize sleep cycles. An absence of orexin A causes narcolepsy, and in animal models, it can alleviate cognitive deficits caused by loss of sleep.
Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573 PMID: 9491897
Deadwyler et al (2007) Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates. J Neurosci. 27(52) 14239 PMID: 18160631
Sakurai (2014) The role of orexin in motivated behaviours. Nat Rev Neurosci. 15(11) 719 PMID: 25301357
Guide to Pharmacology - Orexin A
Related areas
All peptides >
All orexin receptor modulators >
All neuroscience categories >
All endocrinology categories >
All appetite regulation categories >
Technical Data
Structure | Glp-Pro-Leu-Pro-Asp-*Cys-*Cys-Arg-Gln-Lys-Thr-*Cys-Ser-*Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (*disulphide bridges between cysteines 6 and 12, and cysteines 7 and 14) |
CAS Number | 205640-90-0 |
Molecular Weight | 3561.12 |
Formula | C152H243N47O44S4 |
Sequence | XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 |
Modifications | X is Glp, disulphide bridges between cysteines 6 and 12 and cysteines 7 and 14, C-terminal amide |
Solubility and Storage
Solubility | Soluble to 1 mg/ml in water |
Appearance | Freeze dried solid |
Storage | Store dry, frozen and in the dark |
Batch Specific Data
Purity | >95% by hplc |
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