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Products
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H10, biotinylated
Cat. No. PP-010
Structure:
Biotin-Gly-Gly-Gly-Ser-Gly-Met-Lys-Met-Gln-Val-Arg-Ile-Tyr-Leu-Val-OH
Activity:
Biotinylated version of anterior gradient 2 (AGR2) binding peptide H10
H10, biotinylated is the N-terminal biotinylated version of the anterior gradient 2 (AGR2) binding peptide H10 (MKMQVRIYLV) which was identified by mRNA display from a complex (>1011) library. AGR2 is a cancer-associated protein and increased levels of extracellular AGR2 (eAGR2) have been correlated with poor prognosis in cancer patients, making it a potential biomarker. H10 possesses high affinity binding to AGR2 with a KD of 6.4 nM, and has been used as the capture reagent in an AGR2 ELISA. H10 can also inhibit cancer cell migration in breast and prostate cancer cell lines.
Garri et al (2018) Identification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2). Oncotarget 9(44) 27363 PMID: 29937991
Related areas
All biotin labelled peptides >
All protein-protein interaction modulators >
All cancer research categories >
Technical Data
| Structure | Biotin-Gly-Gly-Gly-Ser-Gly-Met-Lys-Met-Gln-Val-Arg-Ile-Tyr-Leu-Val-OH |
| Molecular Weight | 1822.26 |
| Formula | C79H132N22O21S3 |
| Sequence | Biotin-GGGSGMKMQVRIYLV |
| Modifications | Biotinylated at N terminus |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
| Safety Data Sheet | H10, biotinylated MSDS_602bc009f058c.pdf |
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Recent citations
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