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st-Ht31
Cat. No. KS-200
Structure:
Stearyl-Asp-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr-OH
Other Names:
S-Ht31, st-Ht 31 (493-515)
Activity:
AKAP-PKA interaction inhibitor
st-Ht31 is a stearated and cell permeable version of the peptide Ht-31, which inhibits the interaction between the RII subunits of cAMP-dependent PKA and A-kinase anchoring protein (AKAP). The sequence of st-Ht31 is derived from human thyroid RII anchoring protein Ht31, comprising residues 493-515, and is the minimum region of Ht 31 required for RII binding. Disruption of the AKAP-PKA interaction by st-Ht31 alters human airway smooth muscle proliferation and enhances contractile force generation with upregulation of the contractile protein α-sm-actin. st-Ht31 also increases cytosolic PKA activity and is able to reverse foam cell formation and restore metabolic health in otherwise dysfunctional macrophages.
Carr (1992) Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. J Biol Chem. 267(19) 13376 PMID: 1618839
Ma et al (2011) Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. J Biol Chem. 286(5) 3370 PMID: 21106522
Baarsma et al (2020) Disruption of AKAP-PKA Interaction Induces Hypercontractility With Concomitant Increase in Proliferation Markers in Human Airway Smooth Muscle. Front Cell Dev Biol. 8 165 PMID: 32328490
Related areas
All cell penetrating peptides >
All protein-protein interaction modulators >
Technical Data
| Structure | Stearyl-Asp-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr-OH |
| CAS Number | 188425-80-1 |
| Molecular Weight | 2798.27 |
| Formula | C129H217N29O39 |
| Sequence | Stearyl-DLIEEAASRIVDAVIEQVKAAGAY |
| Modifications | N-terminal stearyl |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in 0.01M PBS |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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