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Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
(D)-PPA 1
Cat. No. PP-120
Structure:
H-(D)Asn-(D)Tyr-(D)Ser-(D)Lys-(D)Pro-(D)Thr-(D)Asp-(D)Arg-(D)Gln-(D)Tyr-(D)His-(D)Phe-OH
Other Names:
DPPA-1
Activity:
PD-1/PD-L1 interaction inhibitor
(D)-PPA 1 is a programmed death protein 1/ programmed death-ligand 1 (PD-1/PD-L1) interaction inhibitor. (D)-PPA 1 binds to PD-L1 with a Kd of 0.51 μM and can inhibit interaction at a concentration of 1 mg/mL in flow cytometry experiments. (D)-PPA 1 is a hydrolysis-resistant D-peptide and can disrupt the PD-1/PD-L1 interaction in vivo, inhibiting tumour growth and prolonging survival time in mouse models.
Chang et al (2015) Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy. Angew Chem.Int.Ed.Engl. 54 11760 PMID: 26259671
Sun et al (2018) PD-1/PD-L1 pathway and angiogenesis dual recognizable nanoparticles for enhancing chemotherapy of malignant cancer. Drug Deliv. 25(1) 1746 PMID: 30394118
Related areas
All peptides >
All protein-protein interaction modulators >
Cancer research categories >
Technical Data
| Structure | H-(D)Asn-(D)Tyr-(D)Ser-(D)Lys-(D)Pro-(D)Thr-(D)Asp-(D)Arg-(D)Gln-(D)Tyr-(D)His-(D)Phe-OH |
| CAS Number | 1620813-53-7 |
| Molecular Weight | 1555.67 |
| Formula | C70H98N20O21 |
| Sequence | nyskptdrqyhf |
| Modifications | Asn-1 = D-Asn, Tyr-2 = D-Tyr, Ser-3 = D-Ser, Lys-4 = D-Lys, Pro-5 = D-Pro, Thr-6 = D-Thr, Asp-7 = D-Asp, Arg-8 = D-Arg, Gln-9 = D-Gln, Tyr-10 = D-Tyr, His-11 = D-His, Phe-12 = D-Phe |
Solubility and Storage
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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