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ATN 161
Cat. No. IG-040
Structure:
Ac-Pro-His-Ser-Cys-Asn-NH2
Activity:
α5β1 integrin receptor antagonist
ATN 161 is a α5β1 integrin receptor antagonist that also binds to several other integrins, including α5β1 and αvβ3. ATN 161 is a 5-mer capped peptide derived from the synergy region (PHSRN) of human fibronectin, in which a cysteine residue replaces an arginine in the original sequence (PHSCN). ATN 161 has been shown to inhibit tumour growth, angiogenesis and metastasis and extend survival in multiple animal tumours, it has also shown activity outside oncology and can regress established Crohn's disease in several animal models.
Livant et al (2000) Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma. Cancer Res. 60 309 PMID: 10667582
Khalili et al (2006) A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol.Cancer Ther. 5 2271 PMID: 16985061
Doñate (2008) Pharmacology of the novel antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2): observation of a U-shaped dose-response curve in several preclinical models of angiogenesis and tumor growth. Clin Cancer Res. 14(7) 2137 PMID: 18381955
Related areas
All peptides >
All integrin receptor modulators >
All immunology research categories >
All cancer research categories >
Technical Data
| Structure | Ac-Pro-His-Ser-Cys-Asn-NH2 |
| CAS Number | 262438-43-7 |
| Molecular Weight | 597.65 |
| Formula | C23H35N9O8S |
| Sequence | Ac-PHSCN-NH2 |
| Modifications | N-terminal acetyl, C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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