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Prosaptide TX14(A)
Cat. No. OR-010
Structure:
H-Thr-D-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr-OH
Other Names:
16-29-Saposin C, TX14(A)
Activity:
GPR37 and GPR37L1 agonist
Prosaptide TX14(A) is derived from the active region of saposin C, itself derived from proteolytic processing of prosaposin, a 517-amino acid residue protein and neurotropic factor. Prosaptide Tx 14(A) is a potent agonist of G protein-coupled receptors GPR37 (also known as Parkin-associated endothelin receptor-like receptor Pael-R) and GPR37L1 with EC50 values of 5 nM for GPR37L1 and 7 nM for GPR37. Prosaptide TX14(A) can protect primary astrocytes against oxidative stress, prolongs cell survival in both Schwann cells and oligodendrocytes and has anti-allodynic properties in a rat model of gp120-induced tactile allodynia.
Hiraiwa et al (1997) Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. Proc Natl Acad Sci U S A. 94(9) 4778 PMID: 9114068
Jolivalt et al (2008) Central action of prosaptide TX14(A) against gp120-induced allodynia in rats. Eur J Pain. 12(1) 76 PMID: 17466547
Meyer et al (2013) GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc.Natl.Acad.Sci.USA. 110 9529 PMID: 23690594
Related areas
All peptides >
All orphan 7-TM receptor modulators >
All pain research categories >
Technical Data
| Structure | H-Thr-D-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr-OH |
| CAS Number | 196391-82-9 |
| Molecular Weight | 1579.72 |
| Formula | C69H110N16O26 |
| Sequence | TaLIDNNATEEILY |
| Modifications | Alanine-2 is D configuration |
Solubility and Storage
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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