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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
Foxy 5
Cat. No. PP-110
Structure:
N-Formyl-Met-Asp-Gly-Cys-Glu-Leu-OH
Other Names:
Wnt5a hexapeptide, Foxy5
Activity:
Wnt5a mimetic peptide
Foxy 5 is a formylated hexapeptide derived from the sequence of the Wnt5a ligand which acts as a Wnt5a mimetic. Foxy 5 is able to mimic important effects exerted by the full Wnt5a molecule such as binding to the Frz-5 receptor, and reproducing Wnt5a induced inhibition of human breast cancer cell migration in vitro. Foxy 5 significantly reduces the metastatic spread of WNT5a low DU145 prostate cancer cells in an in vivo orthotopic xenograft mouse model.
Säfholm et al (2006) A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. J.Biol.Chem. 281 2740 PMID: 16330545
Säfholm et al (2008) The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin.Cancer Res. 14 6556 PMID: 18927296
Canesin (2017) Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model. PLoS One 12(9) e0184418 PMID: 28886116
Related areas
All peptides >
All frizzled receptor modulators >
All cancer research categories >
All stem cell research categories >
Technical Data
| Structure | N-Formyl-Met-Asp-Gly-Cys-Glu-Leu-OH |
| CAS Number | 881188-51-8 |
| Molecular Weight | 694.77 |
| Formula | C26H42N6O12S2 |
| Sequence | N-Formyl-MDGCEL |
| Modifications | N-Formylated |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in PBS |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
| Certificate of Analysis | PP-110-1MG Foxy5 Certificate of Analysis_667960cd0c736.pdf |
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