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ATI 2341
Cat. No. CK-010
Structure:
Activity:
ATI 2341 is a pepducin targeting the C-X-C chemokine receptor type 4 (CXCR) at which it is an allosteric agonist with an EC50 of 194 nM. ATI 2341 functions as a biased ligand, favouring Gαi activation over Gα13. In contrast to the the natural CXCR4 agonist, stromal cell-derived factor-1α, ATI 2341 does not promote β-arrestin recruitment. ATI 2341 induces chemotaxis in CXCR4 expressing cells in vitro and acts as a functional antagonist to mobilise polymorphonuclear neutrophils and hematopoietic stem and progenitor cells from bone marrow niche in both mice and non-human primates.
Tchernychev et al (2010) Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc.Natl.Acad.Sci.U.S.A. 107 22255 PMID: 21139054
Quoyer et al (2013) Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc.Natl.Acad.Sci.U.S.A. 110 E5088 PMID: 24309376
Planesas et al (2015) Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor. J.Mol.Graph Model. 60 1 PMID: 26080355
Related areas
All peptides >
All chemokine receptor modulators >
All adhesion molecule research categories >
All immunology research categories >
Technical Data
Structure | Pal-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu-OH |
CAS Number | 1337878-62-2 |
Molecular Weight | 2256.82 |
Formula | C104H178N26O25S2 |
Sequence | Pal-MGYQKKLRSMTDKYRL |
Modifications | N-terminal palmitoyl |
Solubility and Storage
Solubility | Soluble to 1 mg/ml in water |
Appearance | Freeze dried solid |
Storage | Store dry, frozen and in the dark |
Batch Specific Data
Purity | >95% by hplc |
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Recent citations
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