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ATI 2341

Cat. No. CK-010

Structure:

Pal-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu-OH

Activity:

CXCR4 allosteric agonist
Price Qty
1 mg    $ 165.00

ATI 2341 is a pepducin targeting the C-X-C chemokine receptor type 4 (CXCR) at which it is an allosteric agonist with an EC50 of 194 nM.   ATI 2341 functions as a biased ligand, favouring Gαi activation over Gα13.   In contrast to the the natural CXCR4 agonist, stromal cell-derived factor-1α, ATI 2341 does not promote β-arrestin recruitment.  ATI 2341 induces chemotaxis in CXCR4 expressing cells in vitro and acts as a functional antagonist to mobilise polymorphonuclear neutrophils and hematopoietic stem and progenitor cells from bone marrow niche in both mice and non-human primates.

Tchernychev et al (2010) Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc.Natl.Acad.Sci.U.S.A. 107 22255 PMID: 21139054

Quoyer et al (2013) Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc.Natl.Acad.Sci.U.S.A. 110 E5088 PMID: 24309376

Planesas et al (2015) Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor. J.Mol.Graph Model. 60 1 PMID: 26080355


Related areas

All peptides >
All chemokine receptor modulators >
All adhesion molecule research categories >
All immunology research categories >


Technical Data

Structure Pal-Met-Gly-Tyr-Gln-Lys-Lys-Leu-Arg-Ser-Met-Thr-Asp-Lys-Tyr-Arg-Leu-OH
CAS Number 1337878-62-2
Molecular Weight 2256.82
Formula C104H178N26O25S2
Sequence Pal-MGYQKKLRSMTDKYRL
Modifications N-terminal palmitoyl

Solubility and Storage

Solubility Soluble to 1 mg/ml in water
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by hplc

Contact Information

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