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Products
Pharmacology
Type
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- Technical support
- Resources
FSLLRY-NH2
Cat. No. PR-080
Structure:
H-Phe-Ser-Leu-Leu-Arg-Tyr-NH2
Activity:
PAR2 antagonist
FSLLRY-NH2 is a selective PAR2 antagonist. PAR2 is associated with inflammation, metabolism, and disease and FSLLRY-NH2 is correspondingly active in a number of related disease models, it can reverse taxol induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice, it blocks ERK activation and collagen production in isolated cardiac fibroblasts and reduces the level of pro-inflammatory genes IL-8, IL-1β, and TNF-α induced by H2O2 in HepG2 cells. FSLLRY-NH2 reduces symptoms in a mouse model of dermatophyte associated itch and is also effective in human asthma models. This product is sold as the hydrochloride salt.
Andoh et al (2012) Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice. J.Pharmacol.Exp.Ther. 343 91 PMID: 22761302
Lee et al (2017) Inhibitory effect of FSLLRY-NH2 on inflammatory responses induced by hydrogen peroxide in HepG2 cells. Arch Pharm Res. 40(7):854 PMID: 28643288
Ocasio-Rivera et al (2020) Targeting of protease activator receptor-2 (PAR-2) antagonist FSLLRY-NH2 as an asthma adjuvant therapy. Medicine (Baltimore) 99(43) e22351 PMID: 33120736
Related data
All peptides >
All protease activated receptors >
All immunology research categories >
Technical Data
| Structure | H-Phe-Ser-Leu-Leu-Arg-Tyr-NH2 |
| CAS Number | 245329-02-6 |
| Molecular Weight | 796.97 |
| Formula | C39H60N10O8 |
| Sequence | FSLLRY-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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