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AC 187
Cat. No. CG-060
Structure:
Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2
Activity:
Selective amylin antagonist
AC 187 is an orally active, amylin receptor antagonist with an IC50 of 0.48 nM that displays 38 and 400 fold selectivity over calcitonin and CGRP receptors respectively. Blockade of amylin with AC 187 increases glucagon concentration, accelerates gastric emptying of liquids, and results in an exaggerated post-challenge glycemia. AC 187 alone increases feeding when infused into the area postrema.
Rushing (2001) Inhibition of central amylin signaling increases food intake and body adiposity in rats. Endocrinolog 142(11) 5035 PMID: 11606473
Mollet (2004) Infusion of the amylin antagonist AC 187 into the area postrema increases food intake in rats. Physiol Behav. 81(1) 149 PMID: 15059694
Gedulin et al (2006) Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187. Regul.Pept. 137 121 PMID: 16914214
Related areas
All peptides >
All calcitonin and related receptors >
All appetite regulation research categories >
Technical Data
| Structure | Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2 |
| CAS Number | 151804-77-2 |
| Molecular Weight | 2890.25 |
| Formula | C127H205N37O40 |
| Sequence | Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2 |
| Modifications | N-terminal Ac, C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
| Certificate of Analysis | CG-060-1MG AC187_637badb54ff03.pdf |
| Safety Data Sheet | CG-060 AC-187 MSDS_637bada9d70f7.pdf |
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