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Products
Pharmacology
Type
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- Custom services
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- Technical support
- Resources
Dynorphin A
Cat. No. KA-010
Structure:
H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-OH
Other Names:
Dyn A 1-17, Dynorphin A (1-17), Dynorphin 17
Activity:
Endogenous kappa receptor agonist
Dynorphins are a class of opioid peptides that arise from the precursor protein prodynorphin, which when cleaved by proprotein convertase 2, releases multiple active peptides including dynorphin A, dynorphin B, and α/β-neo-endorphin. Dynorphin A is an endogenous kappa receptor agonist and has different physiological actions depending upon its site of production. Dynorphin A is a modulator of pain responses and also has roles in weight control, regulating body temperature, and influencing drug seeking behaviour
Day et al (1998) Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity. J Biol Chem. 273(2) 829 PMID: 9422738
Lai et al (2006) Dynorphin A activates bradykinin receptors to maintain neuropathic pain. Nat Neurosci. 9(12) 1534 PMID: 17115041
Redila and Chavkin (2008) Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system. Psychopharmacology 200(1) 59 PMID: 18575850
Related areas
All peptides >
All κ opioid receptor modulators >
All pain research categories >
Technical Data
| Structure | H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-OH |
| CAS Number | 80448-90-4 |
| Molecular Weight | 2147.51 |
| Formula | C99H155N31O23 |
| Sequence | YGGFLRRIRPKLKWDNQ |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 0.80 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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