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RGDS peptide
Cat. No. IG-030
Structure:
H-Arg-Gly-Asp-Ser-OH
Activity:
Integrin receptor inhibitor
RGDS peptide is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. RGDS interacts with α5β1 and αVβ3 integrins and interferes with the attachment of cells to fibronectin coated surfaces and also blocks the attachment of pathogens to cells. The interaction of RGDS peptide with cell surface integrins alters intracellular signaling in a cell and stimulus specific manner.
Haverstick et al (1985) Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectin. Blood. 66(4) 946 PMID: 3876125
Grigoriou et al (2005) Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J.Biol.Chem. 280 1733 PMID: 15522882
Dekkers et al (2010) The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma. Am J Respir Crit Care Med. 181(6) 556 PMID: 20019343
Related areas
All peptides >
All integrin receptor modulators >
All immunology research categories >
Technical Data
| Structure | H-Arg-Gly-Asp-Ser-OH |
| CAS Number | 91037-65-9 |
| Molecular Weight | 433.42 |
| Formula | C15H27N7O8 |
| Sequence | RGDS |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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