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10Panx
Cat. No. GJ-030
Structure:
H-Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr-OH
Other Names:
Panx-1 mimetic inhibitory peptide, 10Panx1
Activity:
Blocks pannexin-1 gap junctions
10Panx mimics a sequence (WRQAAFVDSY) in the second extracellular loop of Panx1 and is a panx-1 mimetic inhibitory peptide that blocks pannexin 1 gap junctions. 10Panx can inhibit Panx1 hemichannel mediated ATP release and inflammasome activation in astrocytes and macrophages and in vivo, pharmacological blockade of Panx1 hemichannels with 10Panx peptide attenuates the progression of acetaminophen induced hepatotoxicity, neuropathic pain and epilepsy.
Wang et al (2007) Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am.J.Physiol.Cell Physiol. 293 C1112 PMID: 17652431
Bravo et al (2014) Pannexin 1: a novel participant in neuropathic pain signaling in the rat spinal cord. Pain 155(10) 2108 PMID: 25102401
Chen (2019) Enhanced Macrophage Pannexin 1 Expression and Hemichannel Activation Exacerbates Lethal Experimental Sepsis. Sci Rep. 9(1) 160 PMID: 30655582
Related areas
All peptides >
All gap junction channel modulators >
All pain research categories >
All neuroscience research categories >
Technical Data
| Structure | H-Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr-OH |
| CAS Number | 955091-53-9 |
| Molecular Weight | 1242.37 |
| Formula | C58H79N15O16 |
| Sequence | WRQAAFVDSY |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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