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SLIGKV-NH2
Cat. No. PR-060
Structure:
H-Ser-Leu-Ile-Gly-Lys-Val-NH2
Activity:
Protease activated receptor 2 (PAR2) agonist
SLIGKV-NH2 is a protease-activated receptor 2 (PAR2) agonist with a Ki of 9.64 μM and an IC50 of 10.4 μM. SLIGKV-NH2 corresponds to the tethered ligand exposed by trypsin cleavage of PAR-2 and like other peptides corresponding to the tethered ligand sequences of the thrombin receptor and PAR-2 receptor is a full agonist and can be used to investigate receptor function. SLIGKV-NH2 stimulates lactoferrin and IL-8 secretion from human neutrophils.
Bohm et al (1996) Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem.J. 314 1009 PMID: 8615752
Wang and He (2006) Induction of lactoferrin and IL-8 release from human neutrophils by tryptic enzymes via proteinase activated receptor-2. Cell Biol Int. 30(9) 688 PMID: 16820307
Kennedy et al (2018) Structural Characterization of Agonist Binding to Protease-Activated Receptor 2 through Mutagenesis and Computational Modeling. ACS Pharmacol Transl Sci. 1(2) 119 PMID: 32219208
Related data
All peptides >
All protease activated receptors >
All immunology research categories >
Technical Data
| Structure | H-Ser-Leu-Ile-Gly-Lys-Val-NH2 |
| CAS Number | 190383-13-2 |
| Molecular Weight | 614.78 |
| Formula | C28H54N8O7 |
| Sequence | SLIGKV-NH2 |
| Modifications | C-terminal amide) |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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