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Galanin (1-29) (rat, mouse)
Cat. No. GA-030
Structure:
H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-His-Gly-Leu-Thr-NH2
Activity:
Galanin receptor agonist
Galanin (1-29) (rat, mouse) is a non-selective galanin receptor agonist, with Ki values of 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3 respectively. Galanin (1-29) (rat, mouse) is an anticonvulsant which can prevent the occurrence of full kindled seizures in rats. Galanin (1-29) (rat, mouse) causes orexigenic effects in a variety of species.
Fisone et al (1989) Galanin receptor and its ligands in the rat hippocampus. Eur J Biochem. 181(1) 269 PMID: 2469577
Mazarati et al (2006) Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling. J Pharmacol Exp Ther. 318(2) 700 PMID: 16699066
Serebryakova et al (2019) Galanin and its N-terminal fragments reduce acute myocardial infarction in rats. Peptides 111 127 PMID: 29730241
Related areas
All peptides >
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Technical Data
| Structure | H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-His-Gly-Leu-Thr-NH2 |
| CAS Number | 114547-31-8 |
| Molecular Weight | 3164.48 |
| Formula | C141H211N43O41 |
| Sequence | GWTLNSAGYLLGPHAIDNHRSFSDKHGLT-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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