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Products
Pharmacology
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- Technical support
- Resources
UFP 101
Cat. No. NO-010
Structure:
Bn-Gly-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Arg-Lys-Asn-Gln-NH2
Other Names:
[Nphe1,Arg14,Lys15]nociceptin-NH2, [Nphe1, Arg14, Lys15] N/OFQ‐NH2
Activity:
Potent and selective nociceptin receptor antagonist
UFP 101 is a potent, selective and competitive antagonist at the nociceptin receptor. UFP 101 binds to nociceptin receptors with high affinity (pKi 10.24) and possesses ~3000 fold selectivity over the classical opioid receptors. UFP 101 is antinociceptive and opposes the action of nociceptin in vivo, with an antinociceptive effect when given i.c.v. while being inactive following spinal administration in mice. UFP 101 also shows antidepressant effects in distinct species and can reduce microvascular inflammation to lipopolysaccharide in vivo.
Calo et al (2002) [Nphe1,Arg14,Lys15]Nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor. Br.J.Pharmacol. 136 303 PMID: 12010780
Calo et al (2005) UFP-101, a peptide antagonist selective for the nociceptin/orphanin FQ receptor. CNS Drug Rev. 11(2) 97 PMID: 16007234
Brookes et al (2013) The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo. PLoS One 8(9) e74943 PMID: 24086402
Related areas
All peptides >
All nociceptin receptor modulators >
All pain research categories >
All neuroscience research categories >
Technical Data
| Structure | Bn-Gly-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Arg-Lys-Asn-Gln-NH2 |
| CAS Number | 849024-68-6 |
| Molecular Weight | 1908.19 |
| Formula | C82H138N32O21 |
| Sequence | Bn-GGGFTGARKSARKRKNQ-NH2 |
| Modifications | N-terminal benzyl, C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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