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Products
Pharmacology
Type
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- Technical support
- Resources
tcY-NH2
Cat. No. PR-050
Structure:
trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-N2
Other Names:
(trans-Cinnamoyl)-YPGKF-NH2, trans-cinnamoyl-YPGKF-NH2
Activity:
Selective PAR4 antagonist
tcY-NH2 is a selective PAR4 antagonist peptide which can block platelet aggregation caused by thrombin, without affecting ADP mediated aggregation. tcY-NH-2 also blocks PAR4 activation of the ERK pathway and through this mechanism can mediate aortic vascular smooth muscle cell migration and proliferation in rat models.
Hollenberg and Saifeddine (2001) Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides. Can.J.Physiol.Pharmacol. 79 439 PMID: 11405248
Hollenberg et al (2004) Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br.J.Pharmacol. 143 443 PMID: 15451771
Peng (2019) Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function. Front. Immunology 10 1311 PMID: 31275306
Related data
All peptides >
All protease activated receptor modulators >
All cardiovascular research categories >
Technical Data
| Structure | trans-Cinnamoyl-Tyr-Pro-Gly-Lys-Phe-N2 |
| CAS Number | 327177-34-4 |
| Molecular Weight | 739.87 |
| Formula | C40H49N7O7 |
| Sequence | trans-Cinnamoyl-YPGKF-NH2 |
| Modifications | Tyr-1 = trans-Cinnamoyl-Tyr, Phe-5 = C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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