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[D-Lys3]-GHRP-6
Cat. No. GH-200
Structure:
H-His-(D)Trp-(D)Lys-Trp-(D)Phe-Lys-NH2
Other Names:
DLys, [D-Lys3]-Growth Hormone Releasing Peptide 6, [His1, D-Lys3, Lys6]-GHRP
Activity:
Ghrelin receptor (GHS-R1a) antagonist
[D-Lys3]-GHRP-6 is a ghrelin receptor (GHS-R1a) antagonist which also binds weakly to melanocortin receptors. [D-Lys3]-GHRP-6 can decrease energy intake in lean mice, mice with diet induced obesity, and in ob/ob obese mice, and reduces the rate of gastric emptying. [D-Lys3]-GHRP-6 also blocks or reduces ethanol intake and reward seeking in animal models.
Schioth et al (1997) Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31 565 PMID: 9574823
Gomez and Ryabinin (2014) The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice. Alcohol Clin Exp Res. 38(9) 2436 PMID: 25257292
Mosa et al (2018) Long-term treatment with the ghrelin receptor antagonist [d-Lys3]-GHRP-6 does not improve glucose homeostasis in nonobese diabetic MKR mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 314(1) R71 PMID: 28903914
Related areas
All peptides >
All ghrelin receptor modulators >
All endocrinology research categories >
All appetite regulation research categories >
Technical Data
| Structure | H-His-(D)Trp-(D)Lys-Trp-(D)Phe-Lys-NH2 |
| CAS Number | 136054-22-3 |
| Molecular Weight | 930.12 |
| Formula | C49H63N13O6 |
| Sequence | HwkWfK-NH2 |
| Modifications | Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 0.50 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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