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Products
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Gap 26
Cat. No. GJ-020
Structure:
H-Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg-OH
Activity:
Gap junction channel blocker
Gap 26 is a connexin mimetic peptide corresponding to residues 63 - 75 of in the first extracellular loop of connexin 43, which inhibits currents carried by connexin43 hemichannels and gap junction channels. Gap 26 can accelerate wound healing and may have potential in the early treatment of spinal cord injury.
Braet et al (2003) Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium 33 37 PMID: 12526886
Evans and Leybaert (2007) Mimetic peptides as blockers of connexin channel-facilitated intercellular communication. Cell Commun Adhes. 14(6) 265 PMID: 18392994
Desplantez et al (2012) Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels. Pharmacol Res. 65(5) 546 PMID: 22406236
Related areas
All peptides >
All gap junction channel modulators >
All immunology research categories >
Technical Data
| Structure | H-Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg-OH |
| CAS Number | 197250-15-0 |
| Molecular Weight | 1550.79 |
| Formula | C70H107N19O19S |
| Sequence | VCYDKSFPISHVR |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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