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Gap 27
Cat. No. GJ-010
Structure:
H-Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile-OH
Other Names:
Connexin43 mimetic peptide, GAP 27, Connexin mimetic peptide, CMP
Activity:
Selective gap junction channel blocker
Gap 27 is a connexin mimetic peptide corresponding to the SRPTEKTIFFI sequence (amino acids 204–214) on the second extracellular loop of connexin43 (Cx43) which is a selective and reversible inhibitor of Cx43 mediated cell–cell communication, which does not influence Cx43 expression levels. Gap27 effectively inhibits gap junction coupling at concentrations of 50 μM in keratinocytes and HeLa43 cells and is a versatile inhibitor of connexin mediated communication in tissue networks, having been used to identify the role of connexins in cardiomyocyte activities and in pathological processes such as epilepsy.
Ko et al (2000) Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell Physiol. 279 C147 PMID: 10898726
Pollok et al (2011), Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non‐diabetic cells. J. Cellular Molecular Medicine 15 861 PMID: 20345849
Faniku et al (2018) The Connexin Mimetic Peptide Gap27 and Cx43-Knockdown Reveal Differential Roles for Connexin43 in Wound Closure Events in Skin Model Systems. International J. Molecular Sciences 19(2) 604 PMID: 29463027
Related areas
All peptides >
All gap junction channel modulators >
All immunology research categories >
Technical Data
| Structure | H-Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile-OH |
| CAS Number | 198284-64-9 |
| Molecular Weight | 1304.55 |
| Formula | C60H101N15O17 |
| Sequence | SRPTEKTIFII |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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