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Products
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SLIGRL-NH2
Cat. No. PR-030
Structure:
H-Ser-Leu-Ile-Gly-Arg-Leu-NH2
Other Names:
PAR-2 activation peptide, SL-NH2
Activity:
PAR2 activating peptide
SLIGRL-NH2 is an agonist peptide derived from the N-terminus (aas 39-44) of protease-activated receptor 2 (PAR2). SLIGRL-NH2 activates PAR2 with an EC50 of approximately 5 μM and through its effects on PAR2 it stimulates gastric and intestinal smooth muscle contraction. SLIGRL-NH2 is a pruritogen and causes scratching behaviour in mice.
Al-Ani et al (1995) Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can.J.Physiol.Pharmacol. 73 1203 PMID: 8564891
Chung et al (2019) Cathepsin S acts via protease-activated receptor 2 to activate sensory neurons and induce itch-like behaviour, Neurobiology of Pain 6 100032 https://doi.org/10.1016/j.ynpai.2019.100032
Wang et al (2021) Protease-Activated Receptor-2 Decreased Zonula Occlidens-1 and Claudin-1 Expression and Induced Epithelial Barrier Dysfunction in Allergic Rhinitis. American J. Rhinology & Allergy 35(1) 26 PMID: 32551923
Related data
All peptides >
All protease activated receptors >
All immunology research categories >
Technical Data
| Structure | H-Ser-Leu-Ile-Gly-Arg-Leu-NH2 |
| CAS Number | 171436-38-7 |
| Molecular Weight | 656.82 |
| Formula | C29H56N10O7 |
| Sequence | SLIGRL-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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