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IRL 1620
Cat. No. ER-020
Structure:
Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH
Other Names:
Suc-[Glu9,Ala11,15]-endothelin-1(8-21), Sovateltide
Activity:
Highly selective endothelin B receptor agonist
IRL 1620 is an N-succinylated endothelin-1 analogue which acts as a highly selective ETB endothelin receptor agonist, with Ki values of 0.016 and 1900 nM at ETB and ETA receptors respectively. IRL 1620 can also discriminate between two subpopulations of ETB receptors, and in vivo IRL 1620 can significantly reduce neurological and motor deficit as well as infarct volume in a pediatric rat model of cerebral ischemia.
Takai et al (1992) A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor. Biochem.Biophys.Res.Commun. 184 953 PMID: 1315540
Cemazar et al (2005)The endothelin B (ETB) receptor agonist IRL 1620 is highly vasoconstrictive in two syngeneic rat tumour lines: potential for selective tumour blood flow modification. Br J Cancer 93 98 PMID: 15970923
Cifuentes et al (2018) Neuroprotective Effect of IRL-1620, an Endothelin B Receptor Agonist, on a Pediatric Rat Model of Middle Cerebral Artery. Frontiers in Pediatrics 6 310 PMID: 30406063
Ranjan et al (2020) Sovateltide (IRL-1620) activates neuronal differentiation and prevents mitochondrial dysfunction in adult mammalian brains following stroke. Sci Rep. 10(1) 12737 PMID: 32728189
Related areas
All peptides >
All endothelin receptor modulators >
All neuroscience research categories >
All endocrinology research categories >
Technical Data
| Structure | Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH |
| CAS Number | 142569-99-1 |
| Molecular Weight | 1820 |
| Formula | C86H117N17O27 |
| Sequence | Suc-DEEAVYFAHLDIIW |
| Modifications | Asp-1 is succinylated |
Solubility and Storage
| Solubility | Soluble to 0.70 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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