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Products
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- Resources
BQ 3020
Cat. No. ER-010
Structure:
Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH
Activity:
Selective ETB receptor agonist
BQ 3020 is a linear analogue of endothelin-1 (ET-1) which is a highly potent and selective ETB endothelin receptor agonist with Ki values of 0.18 and 970 nM at human ETB and ETA receptors. Intratumour administration of BQ 3020 can attenuate cancer pain by modulating β-endorphin release from squamous cell carcinoma cells in mouse models.
Ekelund et al (1994) Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle. Br.J.Pharmacol. 112 887 PMID: 7921617
Strachan et al (2000) Constriction to ETB receptor agonists, BQ‐3020 and sarafotoxin S6c, in human resistance and capacitance vessels in vivo. British J. Clinical Pharmacology 50: 27 PMID: 10886114
Quang and Schmidt (2010) Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice, PAIN 149(2) 254 PMID: 20206445
Related areas
All peptides >
All endothelin receptor modulators >
All pain research categories >
All endocrinology research categories >
Technical Data
| Structure | Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH |
| CAS Number | 143113-45-5 |
| Molecular Weight | 2006.35 |
| Formula | C96H140N20O25S |
| Sequence | Ac-LMDKEAVYFAHLDIIW |
| Modifications | N terminal acetyl |
Solubility and Storage
| Solubility | Soluble to 0.50 mg/ml in sodium bicarbonate (0.03M) |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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